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Currently, the Responses API is not supported for Anthropic models.

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Quick Start

Use your Helicone API key and the AI Gateway base URL. Then call the OpenAI SDK’s responses.create method as usual. 
import OpenAI from "openai";

const client = new OpenAI({
  apiKey: process.env.HELICONE_API_KEY,
  baseURL: "https://ai-gateway.helicone.ai/v1",
});

const response = await client.responses.create({
  model: "gpt-5",
  input: "Write a one-sentence bedtime story about a unicorn.",
});

console.log(response.output_text);
For Chat Completions usage and more background on the AI Gateway, see the AI Gateway Overview.

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References